PTGER3 and MKLN1

Data Source:
BioGRID (pull down)

		PTGER3	MKLN1
Description		prostaglandin E receptor 3	muskelin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Ubiquitin Ligase Complex Ruffle Nucleoplasm Cytoplasm Cytosol Cell Cortex Postsynapse
	Molecular Function	Prostaglandin E Receptor Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Death Intestine Smooth Muscle Contraction Positive Regulation Of Fever Generation Negative Regulation Of Gastric Acid Secretion	Regulation Of Receptor Internalization Cell-matrix Adhesion Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Reorganization
Pathways		Prostanoid ligand receptors G alpha (i) signalling events
Drugs		Bimatoprost Dinoprostone Misoprostol Gemeprost Limaprost Castor oil
Diseases
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Intelligence (MTAG) ( 29326435) Verbal declarative memory ( 25648963)	Asthma (childhood onset) ( 23829686) Bipolar disorder ( 31043756) Bipolar disorder (early onset) ( 27769005) Cutaneous malignant melanoma ( 32341527) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Hyperglycemia in higher physical activity ( 30327367) Hypertension ( 28273873) Lung cancer in never smokers ( 28604730) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Myeloproliferative neoplasms ( 33057200) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Pancreatic cancer ( 25086665) PR interval ( 30046033 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Systolic blood pressure ( 28135244) Vitamin D levels ( 25208829) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		23 interacting genes: ADAMTSL4 CCDC33 CDA EFEMP2 INCA1 KRT31 KRT38 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MEOX2 MGAT5B MKLN1 NOTCH2NLA PTGER1 REL RGS17 RGS20 SPRY2 TCF4 TRIM42	5 interacting genes: CYREN LAMTOR5 MAEA PTGER3 ZBTB2
Entrez ID		5733	4289
HPRD ID		08906	16129
Ensembl ID		ENSG00000050628	ENSG00000128585
Uniprot IDs		O00325 P43115	B4DG30 Q9UL63
PDB IDs		6AK3 6M9T
Enriched GO Terms of Interacting Partners?
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