ADAMTSL3 and ALPK3

Data Source:
BioGRID (affinity chromatography technology)

		ADAMTSL3	ALPK3
Description		ADAMTS like 3	alpha kinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Matrix Intracellular Membrane-bounded Organelle	Nucleus
	Molecular Function	Metalloendopeptidase Activity Protein Binding	ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Proteolysis Extracellular Matrix Organization	Protein Phosphorylation Heart Development Cardiac Muscle Cell Development
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 28724990) Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Chronic obstructive pulmonary disease ( 30804561) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 20881960 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Lean body mass ( 28724990) Optic disc size ( 31809533) Pulse pressure ( 30224653) Schizophrenia ( 28991256 25056061 29483656 30285260) Spine bone size ( 31053729) Waist circumference ( 26785701) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 26785701 25673412 28448500)	Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Alzheimer's disease (age of onset) ( 22005931) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Metabolite levels ( 23823483) P wave terminal force ( 28794112) PR interval ( 32439900) Schizophrenia ( 29483656)
Interacting Genes		14 interacting genes: CYSRT1 GLRX3 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-6 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP5-7 MDFI NOTCH2NLA
Entrez ID		57188	57538
HPRD ID		12426	11365
Ensembl ID		ENSG00000156218	ENSG00000136383
Uniprot IDs		P82987	Q96L96
PDB IDs
Enriched GO Terms of Interacting Partners?
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