ADAMTSL3 and HDGFL3

Data Source:
BioGRID (biochemical)

		ADAMTSL3	HDGFL3
Description		ADAMTS like 3	HDGF like 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Matrix Intracellular Membrane-bounded Organelle	Extracellular Region Nucleus Nucleoplasm Cytosol
	Molecular Function	Metalloendopeptidase Activity Protein Binding	Double-stranded DNA Binding Transcription Coregulator Activity Microtubule Binding Growth Factor Activity Tubulin Binding
	Biological Process	Proteolysis Extracellular Matrix Organization	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Microtubule Depolymerization Signal Transduction Neuron Projection Development Microtubule Polymerization
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 28724990) Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Chronic obstructive pulmonary disease ( 30804561) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 20881960 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Lean body mass ( 28724990) Optic disc size ( 31809533) Pulse pressure ( 30224653) Schizophrenia ( 28991256 25056061 29483656 30285260) Spine bone size ( 31053729) Waist circumference ( 26785701) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 26785701 25673412 28448500)
Interacting Genes		14 interacting genes: CYSRT1 GLRX3 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-6 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP5-7 MDFI NOTCH2NLA	4 interacting genes: H3C1 SMURF1 SMURF2 TERF2IP
Entrez ID		57188	50810
HPRD ID		12426	17096
Ensembl ID		ENSG00000156218	ENSG00000166503
Uniprot IDs		P82987	A0A024R216 Q9Y3E1
PDB IDs			6IIP 6IIQ 6IIR 6IIS 6IIT
Enriched GO Terms of Interacting Partners?
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