PSMD9 and NCKIPSD

Data Source:
BioGRID (two hybrid)

		PSMD9	NCKIPSD
Description		proteasome 26S subunit, non-ATPase 9	NCK interacting protein with SH3 domain
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Base Subcomplex	Cytosol Intermediate Filament COP9 Signalosome
	Molecular Function	Transcription Coactivator Activity Protein Binding BHLH Transcription Factor Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding
	Biological Process	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Insulin Secretion Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Secretion T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Proteasome Regulatory Particle Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation	Cytoskeleton Organization Positive Regulation Of Neuron Projection Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494) Mean platelet volume ( 24026423) Red blood cell count ( 32888494) Urinary metabolites (H-NMR features) ( 24586186)	Anorexia nervosa ( 31308545) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		20 interacting genes: AHCYL1 BANP BRCA1 CCDC136 CEP85L CKS1B CSH1 ELSPBP1 MEOX2 NCKIPSD PSMC3 PSMC6 RIN3 SKP2 TCF3 TNIP2 TRAF2 TRIM39 TRIM42 YY1	41 interacting genes: ABI2 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GAS7 GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C
Entrez ID		5715	51517
HPRD ID		04394	09450
Ensembl ID		ENSG00000110801	ENSG00000213672
Uniprot IDs		O00233	Q9NZQ3
PDB IDs			6DEC 6DED 6DEE
Enriched GO Terms of Interacting Partners?
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