NUP107 and PPIL3

Data Source:
BioGRID (two hybrid)

		NUP107	PPIL3
Description		nucleoporin 107	peptidylprolyl isomerase like 3
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Nuclear Pore Cytosol Membrane Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Host Cell	Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding
	Biological Process	Posttranscriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Female Gonad Development Viral Process Protein Sumoylation Viral Transcription Nuclear Pore Complex Assembly Regulation Of Gene Silencing By MiRNA Nephron Development Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		White blood cell count ( 20139978)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		3 interacting genes: NUP133 NUP214 SUMO2	6 interacting genes: CENATAC PCBP1 SHARPIN SLU7 TAB2 TAB3
Entrez ID		57122	53938
HPRD ID		06356	15163
Ensembl ID		ENSG00000111581	ENSG00000240344
Uniprot IDs		P57740	A0A024R3V4 A0A0S2Z5A8 Q9H2H8
PDB IDs		3CQC 3CQG 3I4R 5A9Q	1XYH 2OJU 2OK3
Enriched GO Terms of Interacting Partners?
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