TRIM49 and POM121

Data Source:
BioGRID (two hybrid)

		TRIM49	POM121
Description		tripartite motif containing 49	POM121 transmembrane nucleoporin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nuclear Envelope Nuclear Pore Nucleoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Nuclear Membrane Host Cell
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Activity	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore
	Biological Process	Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response	Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways			ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS		Intraocular pressure ( 30591961) Response to taxane treatment (docetaxel) ( 23006423)	Subcutaneous adipose tissue ( 22589738) Triglyceride levels ( 32203549)
Interacting Genes		5 interacting genes: BLM CKS1B LGALS8 MINDY3 POM121	42 interacting genes: AGR2 AP1B1 AP2B1 APC ATXN1 BOLL BRCA1 CCDC57 CEACAM6 CEP55 CEP76 CERT1 CLDN3 COG6 FAM168B FXR2 GFAP GOLGA2 GYG1 HOMER3 JMJD7 KPNA6 LPXN MAGED1 MORN5 NFKBIA OTUD6A PAXIP1 RBPMS SPAG5 STAT3 TEX11 TFIP11 TOX3 TRAF2 TRAF3 TRIM23 TRIM27 TRIM49 TRIP6 UBQLN2 ZMYND12
Entrez ID		57093	9883
HPRD ID		05840	11448
Ensembl ID		ENSG00000168930	ENSG00000196313
Uniprot IDs		E9PK69 P0CI25	Q96HA1
PDB IDs			5T6W
Enriched GO Terms of Interacting Partners?
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