ANKS1B and RIN1

Data Source:
BioGRID (two hybrid, two hybrid)

		ANKS1B	RIN1
Description		ankyrin repeat and sterile alpha motif domain containing 1B	Ras and Rab interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Cajal Body Dendritic Spine Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Ephrin Receptor Binding	GTPase Activator Activity Protein Binding
	Biological Process	Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity By Receptor Localization To Synapse	Endocytosis Signal Transduction Positive Regulation Of GTPase Activity
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat percentage ( 31752434) Body mass index ( 20966902) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Body size at age 10 ( 32376654) Electrodermal activity ( 25387706) Left-handedness ( 32989287) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Response to antipsychotic treatment ( 19721433) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592) Waist circumference ( 20966902)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		13 interacting genes: APP CASS4 EGFR ERBB2 ERBB4 HSF2BP HTR2A LRP1 LRP2 NCK2 RHOA RIN1 UBC	50 interacting genes: ABL1 ABL2 AFDN ANKS1A ANKS1B CALCOCO2 CAPNS2 CARD10 CCM2 CRACR2B EGFR EIF3F ERBB2 ERBB3 GOLGA2 GOLGA6L9 HMG20A HRAS HSF2BP KLHL12 KRT34 KRTAP13-1 KRTAP15-1 LZTS2 MDFI MTDH NRAS PICK1 PLEKHG4 RAB5A RAB5B RALGDS RRAS2 SEC23B SH3RF1 SNX17 SORBS3 SPRED1 TBC1D1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM7 TRIP10 TSC1 YWHAB YWHAE YWHAZ ZBED1
Entrez ID		56899	9610
HPRD ID		07426	05813
Ensembl ID		ENSG00000185046	ENSG00000174791
Uniprot IDs		B1VKB5 B7Z9I9 Q6V0K8 Q7Z6G8	A0A0S2Z4U0 Q13671
PDB IDs		2EAM 2KE7 2KIV 2M38
Enriched GO Terms of Interacting Partners?
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