ERO1B and HMGCS2

Data Source:
BioGRID (affinity chromatography technology)

		ERO1B	HMGCS2
Description		endoplasmic reticulum oxidoreductase 1 beta	3-hydroxy-3-methylglutaryl-CoA synthase 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Thiol Oxidase Activity Unfolded Protein Binding	Hydroxymethylglutaryl-CoA Synthase Activity Identical Protein Binding
	Biological Process	Protein Folding Protein Phosphopantetheinylation Protein Folding In Endoplasmic Reticulum	Acetyl-CoA Metabolic Process Cholesterol Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Lipid Metabolic Process Ketone Body Biosynthetic Process
Pathways		Insulin processing	PPARA activates gene expression Synthesis of Ketone Bodies
Drugs		1-Ethyl-Pyrrolidine-2,5-Dione Flavin adenine dinucleotide
Diseases			HMG-CoA synthase (HMGCS) deficiency
GWAS			Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: BRCA1 ERP44 P4HB	3 interacting genes: APP FBXO7 HSD17B10
Entrez ID		56605	3158
HPRD ID		13279	02580
Ensembl ID		ENSG00000086619	ENSG00000134240
Uniprot IDs		Q86YB8	A0A140VJL2 P54868
PDB IDs			2WYA
Enriched GO Terms of Interacting Partners?
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