LTB4R2 and FOLR1

Data Source:
BioGRID (two hybrid)

		LTB4R2	FOLR1
Description		leukotriene B4 receptor 2	folate receptor alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane	Golgi Membrane Nucleus Endosome Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Clathrin-coated Vesicle Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome
	Molecular Function	Leukotriene B4 Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Protein Binding Folic Acid Binding Signaling Receptor Activity Methotrexate Binding Folic Acid Receptor Activity
	Biological Process	Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Leukotriene Signaling Pathway	Heart Looping Neural Crest Cell Migration Involved In Heart Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Folic Acid Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Sperm-egg Recognition Folic Acid Metabolic Process COPII Vesicle Coating Regulation Of Canonical Wnt Signaling Pathway Pharyngeal Arch Artery Morphogenesis Anterior Neural Tube Closure Cellular Response To Folic Acid Folate Import Across Plasma Membrane
Pathways		Leukotriene receptors G alpha (q) signalling events	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport
Drugs		Amelubant Leukotriene B4	Folic acid Vintafolide Farletuzumab
Diseases
GWAS		Anorectal malformation ( 31136621) Height ( 28552196)
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	6 interacting genes: CUL3 IRAK3 LTB4R2 LYN NCAPH2 SLC35F6
Entrez ID		56413	2348
HPRD ID		16153	00638
Ensembl ID		ENSG00000213906	ENSG00000110195
Uniprot IDs		B4E292 Q9NPC1	A0A024R5H1 P15328
PDB IDs			4KM6 4KM7 4KMX 4LRH 5IZQ
Enriched GO Terms of Interacting Partners?
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