PRODH and ITM2C

Data Source:
BioGRID (biochemical)

		PRODH	ITM2C
Description		proline dehydrogenase 1	integral membrane protein 2C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Intracellular Membrane-bounded Organelle	Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Proline Dehydrogenase Activity FAD Binding	Amyloid-beta Binding Protein Binding ATP Binding
	Biological Process	Proline Metabolic Process Proline Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Proline Catabolic Process To Glutamate Positive Regulation Of Cell Death 4-hydroxyproline Catabolic Process	Negative Regulation Of Neuron Projection Development Neuron Differentiation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Proline catabolism
Drugs		Proline
Diseases		Hyperprolinemia (HP)
GWAS		Amino acid levels ( 26068415) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Metabolic traits ( 21886157) Metabolite levels ( 31628463) Neutrophil count ( 32888494) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free proline levels ( 30659259) Platelet count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 25569235) White blood cell count ( 32888494)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes			11 interacting genes: BACE1 CCL4L2 CXCL9 FNDC9 FURIN MTNR1B OLFM4 RNF7 SLC22A2 STT3A UPK2
Entrez ID		5625	81618
HPRD ID		08433	17167
Ensembl ID		ENSG00000100033	ENSG00000135916
Uniprot IDs		O43272	B8ZZM6 Q9NQX7
PDB IDs
Enriched GO Terms of Interacting Partners?
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