PCDHA6 and RELN

Data Source:
HPRD (in vitro)

		PCDHA6	RELN
Description		protocadherin alpha 6	reelin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Dendrite Neuron Projection
	Molecular Function	Calcium Ion Binding	Serine-type Peptidase Activity Metal Ion Binding Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development	Cell Morphogenesis Involved In Differentiation Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Glial Cell Differentiation Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Spinal Cord Patterning Hippocampus Development Cerebral Cortex Tangential Migration Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Modulation Of Chemical Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Synapse Maturation Positive Regulation Of Long-term Synaptic Potentiation Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity
Pathways			Reelin signalling pathway
Drugs
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Neutrophil count ( 27863252) Schizophrenia ( 29483656) Sum basophil neutrophil counts ( 27863252)	Adult body size ( 32376654) Alzheimer's disease ( 20452100) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Intraocular pressure ( 29785010) Metabolite levels (Pyroglutamine) ( 23934736) Morning person ( 30696823) Multiple sclerosis (age of onset) ( 19010793) Night sleep phenotypes ( 27126917) Otosclerosis ( 19230858) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Schizophrenia ( 18282107) SjÃ¶gren's syndrome ( 28076899) Sucrose liking ( 31005972) Type 2 diabetes ( 30054458 30297969) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		1 interacting genes: RELN	8 interacting genes: DAB1 EFNB2 EFNB3 LRP8 PCDHA4 PCDHA6 SQSTM1 VLDLR
Entrez ID		56142	5649
HPRD ID		07324	02742
Ensembl ID		ENSG00000081842	ENSG00000189056
Uniprot IDs		Q9UN73	P78509
PDB IDs
Enriched GO Terms of Interacting Partners?
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