CFC1 and NDUFS1

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)

		CFC1	NDUFS1
Description		cripto, FRL-1, cryptic family 1	NADH:ubiquinone oxidoreductase core subunit S1
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Extracellular Region Plasma Membrane Cell Surface Anchored Component Of Membrane	Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Intermembrane Space Mitochondrial Matrix
	Molecular Function	Molecular_function Signaling Receptor Binding Nodal Binding Activin Receptor Binding	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Blood Vessel Development Determination Of Left/right Symmetry Gastrulation Heart Development Anterior/posterior Pattern Specification Nodal Signaling Pathway Anatomical Structure Development	Mitochondrial Electron Transport, NADH To Ubiquinone Apoptotic Mitochondrial Changes Mitochondrial Respiratory Chain Complex I Assembly Cellular Respiration ATP Metabolic Process Regulation Of Mitochondrial Membrane Potential Reactive Oxygen Species Metabolic Process
Pathways		Signaling by NODAL Regulation of signaling by NODAL	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases		Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome Heterotaxy; Situs ambiguus	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Body mass index ( 26426971) Chronotype ( 30696823) Frontotemporal dementia with GRN mutation ( 29724592) Morning person ( 30696823)
Interacting Genes			5 interacting genes: C1QTNF9 CASP3 KDM1A MDH2 MDM2
Entrez ID		55997	4719
HPRD ID		05548	01145
Ensembl ID		ENSG00000136698	ENSG00000023228
Uniprot IDs		A0A087WWV2 A0A087WX98 P0CG37	E5KRK5 P28331
PDB IDs			5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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