NDUFS1 and MDH2

Data Source:
HPRD (in vitro)

		NDUFS1	MDH2
Description		NADH:ubiquinone oxidoreductase core subunit S1	malate dehydrogenase 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Intermembrane Space Mitochondrial Matrix	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Binding L-malate Dehydrogenase Activity Protein Self-association Malate Dehydrogenase (NADP+) Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Apoptotic Mitochondrial Changes Mitochondrial Respiratory Chain Complex I Assembly Cellular Respiration ATP Metabolic Process Regulation Of Mitochondrial Membrane Potential Reactive Oxygen Species Metabolic Process	Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADH Metabolic Process Aerobic Respiration
Pathways		Respiratory electron transport Complex I biogenesis	Gluconeogenesis Citric acid cycle (TCA cycle)
Drugs		NADH	NADH Citric acid Xanthinol
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Frontotemporal dementia with GRN mutation ( 29724592) Morning person ( 30696823)	Coffee consumption ( 31959922)
Interacting Genes		5 interacting genes: C1QTNF9 CASP3 KDM1A MDH2 MDM2	8 interacting genes: CRYAB CS FH GOT2 HSPB1 NDUFS1 PC WARS1
Entrez ID		4719	4191
HPRD ID		01145	01099
Ensembl ID		ENSG00000023228	ENSG00000146701
Uniprot IDs		E5KRK5 P28331	A0A024R4K3 B3KTM1 G3XAL0 P40926
PDB IDs		5XTB 5XTD 5XTH 5XTI	2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV
Enriched GO Terms of Interacting Partners?
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