MAPK7 and MFAP4

Data Source:
BioGRID (affinity chromatography technology)

		MAPK7	MFAP4
Description		mitogen-activated protein kinase 7	microfibril associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Microfibril Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Elastic Fiber
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding	Antigen Binding Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Derivative Binding
	Biological Process	MAPK Cascade Cell Cycle Signal Transduction Axon Guidance Peptidyl-serine Phosphorylation CAMP-mediated Signaling Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Complement Activation, Lectin Pathway Cell Adhesion UV Protection Regulation Of Collagen Metabolic Process Elastic Fiber Assembly Cellular Response To UV-B Supramolecular Fiber Organization
Pathways		ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling	Molecules associated with elastic fibres
Drugs		Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644)	Youthful appearance (self-reported) ( 32339537)
Interacting Genes		30 interacting genes: ACTN4 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FOS GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED6CL ZKSCAN1	2 interacting genes: RNF115 SFTPD
Entrez ID		5598	4239
HPRD ID		03952	02789
Ensembl ID		ENSG00000166484	ENSG00000166482
Uniprot IDs		A0A024QZ20 Q13164	A0A024QZ34 P55083
PDB IDs		2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
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