NSFL1C and RPL22

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NSFL1C	RPL22
Description		NSFL1 cofactor	ribosomal protein L22
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Golgi Stack Cytosol Plasma Membrane Spindle Pole Centrosome Intermediate Filament Cytoskeleton VCP-NSFL1C Complex	Nucleus Cytoplasm Cytosol Focal Adhesion Cytosolic Large Ribosomal Subunit Extracellular Exosome Presynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	Protein Binding Phospholipid Binding Ubiquitin Binding ATPase Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Heparin Binding Identical Protein Binding Translation Regulator Activity
	Biological Process	Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Golgi Organization Nuclear Envelope Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Alpha-beta T Cell Differentiation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) TPE interval (resting) ( 32386560)
Interacting Genes		16 interacting genes: ANP32A CDK1 DBI FAM32A GLMN GSK3B LIPE NGLY1 PHAX PRKACA RPL22 SRP14 STX5 TARDBP UBC VCP	23 interacting genes: AP2M1 BAG4 BEND7 CALM1 CDC42 CSE1L CT45A1 DDIT4L DUX4 FGF11 H2BC15 IL7R MAPK14 MDM2 NSFL1C PTEN SDCBP SDCBP2 SRPK2 STAC3 SURF6 THAP1 ZCCHC10
Entrez ID		55968	6146
HPRD ID		09425	01602
Ensembl ID		ENSG00000088833	ENSG00000116251
Uniprot IDs		Q53FE8 Q9UNZ2	P35268
PDB IDs		1SS6	4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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