RCC2 and ERG

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RCC2	ERG
Description		regulator of chromosome condensation 2	ETS transcription factor ERG
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GO Annotations	Cellular Component	Nucleolus Cytosol Microtubule Plasma Membrane Membrane Midbody Early Endosome Membrane Chromosome, Centromeric Core Domain Mitotic Spindle Midzone	Chromatin Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Protein Kinase Binding Protein Domain Specific Binding Small GTPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Cycle Integrin-mediated Signaling Pathway Regulation Of Fibroblast Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Migration Negative Regulation Of GTPase Activity Establishment Of Protein Localization Focal Adhesion Assembly Cell Division Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Chromosome Passenger Complex Localization To Kinetochore Activation Of GTPase Activity Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Ruffle Assembly	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Multicellular Organism Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases			Ewing's sarcoma Prostate cancer
GWAS		Basal cell carcinoma ( 24403052 25855136 27539887 18849993) Non-melanoma skin cancer ( 29739929)	Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Blautia) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (HVA) ( 23319000) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 27386562) Neonatal lupus ( 20662065) Neutrophil count ( 32888494) Non-response to antidepressants and depression ( 27622933) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)
Interacting Genes		4 interacting genes: ERG PRPF40A PTEN RAC1	74 interacting genes: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HERC2 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 PVT1 RCC2 RING1 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SPOP STUB1 SYN1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X XRN2
Entrez ID		55920	2078
HPRD ID		18171	01298
Ensembl ID		ENSG00000179051	ENSG00000157554
Uniprot IDs		A0A024RAC5 Q9P258	A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308
PDB IDs		5GWN	1SXE 4IRG 4IRH 4IRI 5YBC 5YBD
Enriched GO Terms of Interacting Partners?
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