SELENOS and TM2D3

Data Source:
BioGRID (genetic interference)

		SELENOS	TM2D3
Description		selenoprotein S	TM2 domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex	Spanning Component Of Plasma Membrane
	Molecular Function	Protein Binding Antioxidant Activity Enzyme Binding Signaling Receptor Activity ATPase Binding Ubiquitin-specific Protease Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis ER Overload Response Response To Glucose Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Positive Regulation Of Notch Signaling Pathway Lateral Inhibition
Pathways		E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Triglyceride levels ( 32154731)
Interacting Genes		9 interacting genes: APOA5 DERL1 GTF2IRD1 KLHDC2 KPNB1 MFHAS1 SAA1 SRPK2 VCP	2 interacting genes: ERRFI1 PAXIP1
Entrez ID		55829	80213
HPRD ID		12133	16554
Ensembl ID		ENSG00000131871	ENSG00000184277
Uniprot IDs		Q6GYA4 Q9BQE4	B4DLL2 E7EPS7 H0YNS4 Q9BRN9
PDB IDs		2Q2F 5KIU 5KIY 6DO4
Enriched GO Terms of Interacting Partners?
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