VPS35 and SLC11A2

Data Source:
BioGRID (pull down)

		VPS35	SLC11A2
Description		VPS35 retromer complex component	solute carrier family 11 member 2
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GO Annotations	Cellular Component	Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Retromer Complex Retromer, Cargo-selective Complex Extracellular Exosome Tubular Endosome Mitochondrion-derived Vesicle	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosomal Membrane Early Endosome Vacuole Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Cytoplasmic Vesicle Brush Border Membrane Late Endosome Membrane Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Paraferritin Complex Extracellular Vesicle
	Molecular Function	Protein Binding D1 Dopamine Receptor Binding	Copper Ion Transmembrane Transporter Activity Iron Ion Transmembrane Transporter Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Cadmium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Nickel Cation Transmembrane Transporter Activity Solute:proton Symporter Activity Cadmium Ion Binding Transition Metal Ion Transmembrane Transporter Activity
	Biological Process	Intracellular Protein Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Viral Process Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Regulation Of Cellular Protein Metabolic Process Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Mitochondrial Fission Mitochondrion To Lysosome Transport Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Negative Regulation Of Neuron Death Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Presynapse Assembly Retrograde Transport, Endosome To Plasma Membrane Regulation Of Terminal Button Organization	Response To Hypoxia Heme Biosynthetic Process Cobalt Ion Transport Copper Ion Transport Iron Ion Transport Manganese Ion Transport Cellular Iron Ion Homeostasis Learning Or Memory Response To Iron Ion Lead Ion Transport Iron Import Into Cell Iron Ion Transmembrane Transport Copper Ion Transmembrane Transport Nickel Cation Transmembrane Transport Dendrite Morphogenesis Erythrocyte Development Multicellular Organismal Iron Ion Homeostasis Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Proton Transmembrane Transport
Pathways		WNT ligand biogenesis and trafficking	Metal ion SLC transporters Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) Iron uptake and transport
Drugs			Ferric maltol
Diseases
GWAS
Interacting Genes		12 interacting genes: APP DRD1 LINC01554 MTNR1B SLC11A2 SNX1 SNX3 VEGFA VPS26A VPS26B VPS29 ZNF512B	1 interacting genes: VPS35
Entrez ID		55737	4891
HPRD ID		06085	02750
Ensembl ID		ENSG00000069329	ENSG00000110911
Uniprot IDs		Q96QK1	A0A0X8GKR4 P49281
PDB IDs		2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI	5F0L 5F0M 5F0P
Enriched GO Terms of Interacting Partners?
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