IWS1 and AKT3

Data Source:
BioGRID (enzymatic study)

		IWS1	AKT3
Description		interacts with SUPT6H, CTD assembly factor 1	AKT serine/threonine kinase 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm Membrane
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Processing RNA Splicing Regulation Of MRNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus Regulation Of MRNA Processing MRNA Transport Regulation Of Histone H4 Acetylation Regulation Of Histone H3-K36 Trimethylation	Mitochondrial Genome Maintenance Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Signal Transduction Peptidyl-serine Phosphorylation Positive Regulation Of TOR Signaling Intracellular Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Size Brain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Negative Regulation Of Cellular Senescence
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Cardiac troponin-I levels ( 31014085)	Adult body size ( 32376654) Adult diffuse glioma (IDH mutation) ( 32386320) Adventurousness ( 30643258) Antisaccade task score ( 31596458) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diabetic retinopathy ( 21441570) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) Height ( 28552196) Menarche (age at onset) ( 23599027) Non-glioblastoma glioma ( 28346443) Platelet distribution width ( 32888494) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Self-reported risk-taking behaviour ( 30181555) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: AKT1 AKT3 CSNK2A1 ERCC6 ERICH2 KRTAP10-3 POLR2A STAT2 SUPT6H TCEA1	11 interacting genes: FBXO7 GSK3B IWS1 NEDD4 NEDD4L PDPK1 PPP2CA PRKCD PRKCZ TCL1A TSC2
Entrez ID		55677	10000
HPRD ID		07639	06441
Ensembl ID		ENSG00000163166	ENSG00000117020
Uniprot IDs		Q96ST2	A0A5F9ZHU3 Q9Y243
PDB IDs		6EMR	2X18
Enriched GO Terms of Interacting Partners?
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