POMGNT1 and CXorf66

Data Source:
BioGRID (two hybrid)

		POMGNT1	CXorf66
Description		protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	chromosome X open reading frame 66
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Integral Component Of Golgi Membrane	Integral Component Of Membrane
	Molecular Function	Protein Binding Acetylglucosaminyltransferase Activity Manganese Ion Binding Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity	Protein Binding
	Biological Process	Protein O-linked Glycosylation O-glycan Processing Protein Phosphopantetheinylation
Pathways		Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 O-linked glycosylation
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Dystroglycanopathy; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama congenital muscular dystrophy (FCMD); Congenital muscular dystrophy with muscle hypertrophy (MDC1C); Congenital muscular dystrophy with severe intellectual impairment and abnormal glycosylation (MDC1D) Limb-girdle muscular dystrophy (LGMD)
GWAS		Body mass index ( 26426971)
Interacting Genes		11 interacting genes: BRCA1 CD74 CISD2 CXCL8 CXorf66 ERGIC3 LNX1 RXYLT1 SOX6 TMEM237 ZBTB18	12 interacting genes: AQP6 ASPH EMD ERGIC3 LAT POMGNT1 RPRM RTP2 STX10 TMEM31 TMX2 YIPF6
Entrez ID		55624	347487
HPRD ID		09493	18139
Ensembl ID		ENSG00000085998	ENSG00000203933
Uniprot IDs		B7Z7F2 B7Z7Q4 Q8WZA1	Q5JRM2
PDB IDs		5GGF 5GGG 5GGI 5GGJ 5GGK 5GGL 5GGN 5GGO 5GGP 5XFC
Enriched GO Terms of Interacting Partners?
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