DNAJA4 and WDR61

Data Source:
HPRD (in vivo)

		DNAJA4	WDR61
Description		DnaJ heat shock protein family (Hsp40) member A4	WD repeat domain 61
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Transcriptionally Active Chromatin Ski Complex
	Molecular Function	Protein Binding ATP Binding Heat Shock Protein Binding Metal Ion Binding Unfolded Protein Binding Chaperone Binding	Protein Binding
	Biological Process	Response To Heat Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Protein Refolding Negative Regulation Of Inclusion Body Assembly	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Wnt Signaling Pathway Protein Ubiquitination Exonucleolytic Catabolism Of Deadenylated MRNA Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Histone H3-K79 Methylation
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR)	Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intracranial aneurysm ( 29531279) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Reticulocyte count ( 32888494)
Interacting Genes		3 interacting genes: BANP ERG SH3BP4	11 interacting genes: ACVR1 BARD1 ERRFI1 EZH2 MCPH1 MSRB3 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ
Entrez ID		55466	80349
HPRD ID		09920	15236
Ensembl ID		ENSG00000140403	ENSG00000140395
Uniprot IDs		Q69YX3 Q8WW22	H0YL19 Q9GZS3
PDB IDs			3OW8 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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