PRCC and MAD2L2

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vitro, in vivo)

		PRCC	MAD2L2
Description		proline rich mitotic checkpoint control factor	mitotic arrest deficient 2 like 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Nucleolus Spindle Cytosol Zeta DNA Polymerase Complex Site Of Double-strand Break
	Molecular Function	Protein Binding	RNA Polymerase II Activating Transcription Factor Binding Protein Binding JUN Kinase Binding
	Biological Process	MRNA Splicing, Via Spliceosome Mitotic Cell Cycle Checkpoint	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Double-strand Break Repair Actin Filament Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Isotype Switching Positive Regulation Of Transcription, DNA-templated Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		mRNA Splicing - Major Pathway	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases		Renal cell carcinoma
GWAS		SjÃ¶gren's syndrome ( 28076899)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		8 interacting genes: CSNK2A1 EGFR HOMER3 MAD2L2 PPIL2 RBM10 SRSF2 TOE1	47 interacting genes: ADAM15 ADAM17 ADAM9 C20orf85 CAMK2B CDC20 CDH1 DEPDC5 ELK1 FAM217B FTO FZR1 GSC2 IKZF1 IKZF3 INCA1 KCTD9 KRT34 MAD2L1 MAD2L1BP MBD3L1 MYBPC2 PLAGL2 POLDIP2 PPM1B PRCC PRR5L PRRC2A RAB11FIP4 RBBP6 REL REV1 REV3L SFI1 SHLD1 TCF4 THAP6 TRIM27 TRIM54 TRIM7 YPEL3 YY1AP1 ZBED1 ZMYND12 ZNF511 ZNF558 ZNF655
Entrez ID		5546	10459
HPRD ID		01562	07246
Ensembl ID		ENSG00000143294	ENSG00000116670
Uniprot IDs		A0A0S2Z456 A0A0S2Z470 Q92733 Q96FT4	A0A024R4I4 Q9UI95
PDB IDs			3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6K07 6K08 6KEA 6KTO 6NIF
Enriched GO Terms of Interacting Partners?
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