LGR4 and MARCHF2

Data Source:
BioGRID (two hybrid)

		LGR4	MARCHF2
Description		leucine rich repeat containing G protein-coupled receptor 4	membrane associated ring-CH-type finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endosome Membrane Integral Component Of Membrane Cytoplasmic Vesicle
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cytokine Production Hair Follicle Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Hormone-mediated Signaling Pathway Bone Mineralization Male Genitalia Development Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor Signaling Pathway Intestinal Stem Cell Homeostasis Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Bone Remodeling Digestive Tract Development Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cell Differentiation Involved In Metanephros Development Metanephric Glomerulus Development Metanephric Nephron Tubule Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis	Endocytosis Protein Ubiquitination
Pathways		Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Bone mineral density ( 23644456) Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Dental caries (decayed, missing and filled teeth) ( 31533690) Heel bone mineral density ( 30598549) Male-pattern baldness ( 28196072) Menarche (age at onset) ( 25231870) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Survival in pancreatic cancer ( 28470677) Urate levels in obese individuals ( 25811787)
Interacting Genes		5 interacting genes: MARCHF2 RSPO1 RSPO2 RSPO3 RSPO4	30 interacting genes: AQP6 CCL4 CD79A CDC34 CFTR CREB3L1 ERGIC3 F11R FAM209A FATE1 GJA8 GPX8 KASH5 LDLRAD1 LGR4 MUC1 PEX12 PLPPR2 SCN3B SSMEM1 STX6 SYNE4 TMEM106C TMEM179B TMEM52B TMEM86B TSPAN12 TSPO2 UBE2D1 UBE2H
Entrez ID		55366	51257
HPRD ID		05978	14361
Ensembl ID		ENSG00000205213	ENSG00000099785
Uniprot IDs		Q59ER8 Q9BXB1	Q9P0N8
PDB IDs		4KT1 4QXE 4QXF
Enriched GO Terms of Interacting Partners?
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