AVPR1B and AVP

Data Source:
HPRD (in vivo)

		AVPR1B	AVP
Description		arginine vasopressin receptor 1B	arginine vasopressin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite Clathrin-coated Vesicle Membrane
	Molecular Function	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Kinase C Binding Peptide Binding	Protein Kinase Activity Signaling Receptor Binding Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Phospholipase A2 Activity Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Vasoconstriction Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Arachidonic Acid Secretion Transport Across Blood-brain Barrier	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Generation Of Precursor Metabolites And Energy Protein Phosphorylation Water Transport Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Testosterone Response To Nicotine Social Behavior Regulation Of Renal Sodium Excretion Vasoconstriction Hyperosmotic Salinity Response Maternal Behavior Negative Regulation Of Apoptotic Process Penile Erection Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of Vasoconstriction Negative Regulation Of Transmission Of Nerve Impulse Membrane Organization ERK1 And ERK2 Cascade Protein Kinase C Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)	BMAL1:CLOCK,NPAS2 activates circadian gene expression Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Transport of organic anions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production
Drugs		Desmopressin Vasopressin Terlipressin PH-284 SR 121463 Atosiban Lypressin
Diseases			Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus
GWAS
Interacting Genes		2 interacting genes: AVP GRK5	9 interacting genes: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR PRKAB2 TXNDC17
Entrez ID		553	551
HPRD ID		02600	01891
Ensembl ID		ENSG00000198049	ENSG00000101200
Uniprot IDs		P47901	P01185 X5DQP6
PDB IDs
Enriched GO Terms of Interacting Partners?
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