PHF10 and STAM2

Data Source:
BioGRID (two hybrid)

		PHF10	STAM2
Description		PHD finger protein 10	signal transducing adaptor molecule 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm NpBAF Complex	Nucleoplasm Cytoplasm Cytosol Endocytic Vesicle Early Endosome Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coregulator Activity Histone Binding Metal Ion Binding	Protein Binding
	Biological Process	Nervous System Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Intracellular Protein Transport Signal Transduction Endosomal Transport Macroautophagy Protein Deubiquitination Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization
Pathways			EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Type 1 diabetes ( 21980299)	Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)
Interacting Genes		9 interacting genes: APLP1 CELSR2 L3MBTL2 LIG4 SETDB1 STAM2 UNC119 UTP14A VAV2	39 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 CDC7 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN1 UBQLN2 UBQLN4 USP8 VPS37C XRN1 ZC3H10
Entrez ID		55274	10254
HPRD ID		11428	05876
Ensembl ID		ENSG00000130024	ENSG00000115145
Uniprot IDs		Q8WUB8	O75886
PDB IDs			1X2Q 1X5B 2L0T 5CRV 5IXF
Enriched GO Terms of Interacting Partners?
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