PTPA and GRIN3A

Data Source:
BioGRID (two hybrid)

		PTPA	GRIN3A
Description		protein phosphatase 2 phosphatase activator	glutamate ionotropic receptor NMDA type subunit 3A
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome	Plasma Membrane Postsynaptic Density Membrane Integral Component Of Membrane NMDA Selective Glutamate Receptor Complex Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity ATPase Activity Protein Phosphatase Regulator Activity Protein Homodimerization Activity Protein Phosphatase 2A Binding	NMDA Glutamate Receptor Activity Calcium Channel Activity Protein Binding Ligand-gated Ion Channel Activity Glycine Binding Signaling Receptor Activity Identical Protein Binding Protein Phosphatase 2A Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Peptidyl-prolyl Isomerization Mitotic Spindle Organization Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity	Calcium Ion Transport Dendrite Development Ionotropic Glutamate Receptor Signaling Pathway Response To Ethanol Regulation Of Postsynaptic Membrane Potential Prepulse Inhibition Calcium Ion Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways			Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Profenamine Secobarbital Dextromethorphan Acamprosate Procaine Donepezil Guaifenesin Ethanol Amantadine Memantine Halothane Orphenadrine Phenobarbital Ketamine Aripiprazole Tenocyclidine Rolicyclidine Prasterone Phencyclidine Milnacipran Neramexane Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS			Alzheimer disease and age of onset ( 26830138) Asthma ( 27611488) Coronary artery aneurysm in Kawasaki disease ( 26434682) Coronary artery calcification ( 23870195) Glucocorticoid-induced osteonecrosis ( 26265699) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Glucocorticoid-induced osteonecrosis (time dependent analysis) ( 26265699) Obesity-related traits ( 23251661) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Plasma anti-thyroid peroxidase levels ( 29678681) Response to fenofibrate (triglyceride levels) ( 27002377) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		28 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SPG21 SRC SULT4A1	6 interacting genes: DLG4 DYNLL1 GRIN1 GRIN2A GRIN2B PTPA
Entrez ID		5524	116443
HPRD ID		02858	09443
Ensembl ID		ENSG00000119383	ENSG00000198785
Uniprot IDs		B4DZF8 F6WIT2 Q15257	Q8TCU5
PDB IDs		2G62 2HV6 2HV7 2IXM 4LAC 4NY3
Enriched GO Terms of Interacting Partners?
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