FANCI and FANCD2

Data Source:
HPRD (in vitro)

		FANCI	FANCD2
Description		FA complementation group I	FA complementation group D2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body
	Molecular Function	DNA Binding Protein Binding DNA Polymerase Binding	Protein Binding DNA Polymerase Binding
	Biological Process	Cell Cycle Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair	Homologous Chromosome Pairing At Meiosis Gamete Generation Response To Gamma Radiation Intra-S DNA Damage Checkpoint Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases		Fanconi anemia	Fanconi anemia
GWAS		Height ( 25282103) Menopause (age at onset) ( 26414677) Red cell distribution width ( 32888494) Serum immune biomarker levels ( 32066700)	Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		13 interacting genes: AKT1 APP ATR BRCA2 FANCD2 FANCL MTDH MTNR1B PIAS1 RAD51 UBL5 USP1 WDR48	28 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1
Entrez ID		55215	2177
HPRD ID		13339	01968
Ensembl ID		ENSG00000140525	ENSG00000144554
Uniprot IDs		B3KNW8 Q9NVI1	Q9BXW9
PDB IDs		6VAA 6VAD 6VAE 6VAF	6VAA 6VAD 6VAE 6VAF
Enriched GO Terms of Interacting Partners?
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