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AVPR1A and AVP
Data Source:
HPRD
(in vivo)
AVPR1A
AVP
Description
arginine vasopressin receptor 1A
arginine vasopressin
Image
No pdb structure
GO Annotations
Cellular Component
Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Endocytic Vesicle
Extracellular Region
Extracellular Space
Cytosol
Secretory Granule
Dendrite
Clathrin-coated Vesicle Membrane
Molecular Function
G Protein-coupled Receptor Activity
Vasopressin Receptor Activity
Protein Kinase C Binding
Protein Binding
Peptide Hormone Binding
V1A Vasopressin Receptor Binding
Peptide Binding
Protein Kinase Activity
Signaling Receptor Binding
Neuropeptide Hormone Activity
Neurohypophyseal Hormone Activity
Protein Binding
V1A Vasopressin Receptor Binding
V1B Vasopressin Receptor Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Biological Process
Regulation Of Systemic Arterial Blood Pressure By Vasopressin
Maternal Aggressive Behavior
Positive Regulation Of Systemic Arterial Blood Pressure
Generation Of Precursor Metabolites And Energy
G Protein-coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Negative Regulation Of Female Receptivity
Grooming Behavior
Blood Circulation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Heart Rate
Positive Regulation Of Glutamate Secretion
Myotube Differentiation
Calcium-mediated Signaling
Telencephalon Development
Positive Regulation Of Cell Growth
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Cellular PH Reduction
Social Behavior
Positive Regulation Of Renal Sodium Excretion
Cellular Response To Water Deprivation
Maternal Behavior
Sperm Ejaculation
Penile Erection
Positive Regulation Of Vasoconstriction
Response To Corticosterone
Negative Regulation Of Transmission Of Nerve Impulse
Transport Across Blood-brain Barrier
Maternal Aggressive Behavior
Positive Regulation Of Systemic Arterial Blood Pressure
Renal Water Homeostasis
Generation Of Precursor Metabolites And Energy
Protein Phosphorylation
Water Transport
Apoptotic Process
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Negative Regulation Of Female Receptivity
Grooming Behavior
Locomotory Behavior
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Glutamate Secretion
Positive Regulation Of Cell Growth
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Cellular PH Reduction
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Testosterone
Response To Nicotine
Social Behavior
Regulation Of Renal Sodium Excretion
Vasoconstriction
Hyperosmotic Salinity Response
Maternal Behavior
Negative Regulation Of Apoptotic Process
Penile Erection
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Ethanol
Positive Regulation Of Vasoconstriction
Negative Regulation Of Transmission Of Nerve Impulse
Membrane Organization
ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Pathways
Vasopressin-like receptors
G alpha (q) signalling events
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Vasopressin-like receptors
G alpha (q) signalling events
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Transport of organic anions
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Desmopressin
Vasopressin
Felypressin
Conivaptan
Terlipressin
PH-284
Tolvaptan
Atosiban
Relcovaptan
Lypressin
Diseases
Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus
GWAS
Chronotype (
30696823
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Hippocampal volume (
29860282
)
Morning person (
30696823
)
Type 2 diabetes (
31049640
)
Interacting Genes
3 interacting genes:
AVP
GRK5
PRKCA
9 interacting genes:
AVPR1A
AVPR1B
AVPR2
CRYAB
DLX2
KMT2A
OXTR
PRKAB2
TXNDC17
Entrez ID
552
551
HPRD ID
02894
01891
Ensembl ID
ENSG00000166148
ENSG00000101200
Uniprot IDs
P37288
X5D2B0
P01185
X5DQP6
PDB IDs
1YTV
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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