Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
FAM90A1 and SPRED1
Data Source:
BioGRID
(two hybrid)
FAM90A1
SPRED1
Description
family with sequence similarity 90 member A1
sprouty related EVH1 domain containing 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Plasma Membrane
Caveola
Cytoplasmic Vesicle
Molecular Function
Protein Binding
Stem Cell Factor Receptor Binding
Protein Binding
Protein Kinase Binding
Phosphatase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Biological Process
MAPK Cascade
Inactivation Of MAPK Activity
Negative Regulation Of Protein Kinase Activity
Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Phosphatase Activity
Negative Regulation Of Angiogenesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of MAPK Cascade
Negative Regulation Of MAPK Cascade
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Vasculogenesis Involved In Coronary Vascular Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Protein Deacetylation
Negative Regulation Of Lens Fiber Cell Differentiation
Pathways
Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling
RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Gut microbiota (functional units) (
27694959
)
Bipolar disorder (
20351715
)
Birth weight (
31043758
)
Cognitive performance (processing speed) (
31598132
)
Crohn's disease (
23128233
)
Erosive tooth wear (severe vs non-severe) (
29898447
)
Erosive tooth wear (severe vs none or mild) (
29898447
)
HDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
Hypersomnia (HLA-DQB1*06:02 negative) (
23646285
)
Interacting Genes
162 interacting genes:
ABI2
ACTN3
AKAP9
AMOTL2
ANKRD23
ANKRD29
AP2M1
APP
ARHGEF9
ARRDC3
BANP
BCAR1
BEGAIN
BHLHB9
BLZF1
CADPS
CALCOCO2
CARD9
CCDC13
CCDC57
CCN3
CCNC
CCNL2
CDR2
CEP55
CEP70
CEP72
CEP76
CHRDL2
COG6
CYSRT1
DTX3
DVL2
DVL3
EFEMP2
ENKD1
EXOSC8
FAM228A
FHL3
FLACC1
FLOT1
FOSB
FSD2
FXR1
FXR2
FYN
GABPB1
GCSAML
GNPTAB
GOLGA2
GOPC
GPSM1
GRIPAP1
HAND2
HMBOX1
HOMER3
HOMEZ
HOOK2
HSF2BP
ISY1
KANK2
KASH5
KIFC3
KLHL12
KPNA3
KPNA6
KRT31
KRT34
KRT38
KRT40
KRTAP1-1
KRTAP10-8
LDOC1
LHX6
LIMS1
LMO2
LNX1
LRP2BP
LRRK2
LZTS1
LZTS2
MAD1L1
MDFI
MEIS3
MID2
MIPOL1
MLH1
MORN3
MSS51
MTUS2
MYOG
NBPF19
NDUFB7
NOTCH2NLA
NUDT21
OVOL1
PBX1
PBX2
PDLIM7
PFDN5
PICK1
PIH1D1
PLAGL2
POF1B
PPARA
PPP1R13B
PRDM6
PRKAR1B
PRR23B
PSME3
PSTPIP1
RAB11FIP2
RABEP1
RBM48
REL
RHOH
RINT1
ROPN1
RPRD1A
SH2B2
SIAH1
SMAD3
SMARCB1
SNW1
SPRED1
SRPK2
STAC3
STMN2
STX11
TAX1BP1
TEPSIN
TFIP11
TLE5
TMCC2
TRAF2
TRAF4
TRIB3
TRIM23
TRIM27
TRIM42
TRIM54
TRIM55
TRIM69
TRIM9
TRIML2
VRTN
VWC2
ZBTB14
ZBTB16
ZBTB7B
ZBTB8A
ZC2HC1C
ZMYND12
ZNF143
ZNF212
ZNF343
ZNF526
ZNF581
ZNF655
ZNF688
ZNF76
ZWINT
37 interacting genes:
ANKS1A
AQP1
BEX2
BLZF1
C2orf68
CCDC185
CDKN1A
CREB5
DNAJB11
FAM118B
FAM90A1
GLYCTK
HEXIM2
HPCAL4
HSF2BP
IL16
KIT
MAB21L3
MEOX2
NAGK
NCALD
OSGEP
PIH1D2
PPP1CA
PPP1R7
PRPF18
RCC1
RIN1
SPG21
SUV39H1
TSC22D1
TTC19
VSNL1
ZNF408
ZNF417
ZNF587
ZNF655
Entrez ID
55138
161742
HPRD ID
07672
11601
Ensembl ID
ENSG00000171847
ENSG00000166068
Uniprot IDs
Q86YD7
Q7Z699
PDB IDs
3SYX
6V65
6V6F
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?