SLFN12 and CDK12

Data Source:
HPRD (in vivo)

		SLFN12	CDK12
Description		schlafen family member 12	cyclin dependent kinase 12
Image		No pdb structure
GO Annotations	Cellular Component		Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex
	Molecular Function	Protein Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Kinase Binding Cyclin Binding
	Biological Process		Transcription Elongation From RNA Polymerase II Promoter MRNA Processing Protein Phosphorylation RNA Splicing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MAP Kinase Activity Regulation Of RNA Splicing Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Stem Cell Differentiation
Pathways			TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
GWAS			Asthma ( 31619474) Blood urea nitrogen levels ( 31152163) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Lung function (FVC) ( 30061609) Menopause (age at onset) ( 26414677) Refractive error ( 32231278) Triglyceride levels ( 30108155)
Interacting Genes		4 interacting genes: JMJD6 SUV39H1 TRIM55 TRIM63	9 interacting genes: CLK1 EWSR1 MBP PIN1 POLR2A PRPF40A SRPK2 SRSF1 SRSF2
Entrez ID		55106	51755
HPRD ID		08543	10849
Ensembl ID		ENSG00000172123	ENSG00000167258
Uniprot IDs		Q8IYM2	Q9NYV4
PDB IDs			4CXA 4NST 4UN0 5ACB 6B3E 6CKX 6TD3
Enriched GO Terms of Interacting Partners?
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