UACA and SMAD6

Data Source:
HPRD (in vivo)

		UACA	SMAD6
Description		uveal autoantigen with coiled-coil domains and ankyrin repeats	SMAD family member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytosol Cytoskeleton Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Protein-containing Complex Heteromeric SMAD Protein Complex
	Molecular Function	Molecular_function Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Type I Activin Receptor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Biological_process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling	Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Negative Regulation Of SMAD Protein Complex Assembly Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Coronary Vasculature Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Regulation of the apoptosome activity	Signaling by BMP RUNX2 regulates bone development
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Pulmonary function ( 23932459)	Asthma ( 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Carpal tunnel syndrome ( 30833571) Dental caries (decayed and filled deciduous teeth) ( 31533690) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Lung cancer (smoking interaction) ( 24658283) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Severe aortic features in Marfan syndrome ( 30087447) Subcutaneous adipose tissue ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		13 interacting genes: AHCYL1 ANKRD28 CCDC125 CELSR3 HIF1AN JPH1 KRT31 KRT40 MED14 PRKAR1B RTP2 STAMBP UBQLN2	17 interacting genes: BMPR1B CHRM5 HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1
Entrez ID		55075	4091
HPRD ID		11657	04240
Ensembl ID		ENSG00000137831	ENSG00000137834
Uniprot IDs		Q9BZF9	O43541
PDB IDs
Enriched GO Terms of Interacting Partners?
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