PINX1 and PTP4A3

Data Source:
BioGRID (affinity chromatography technology)

		PINX1	PTP4A3
Description		PIN2 (TERF1) interacting telomerase inhibitor 1	protein tyrosine phosphatase 4A3
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleoplasm Nucleolus Mitochondrion Spindle	Nucleus Cytoplasm Early Endosome Plasma Membrane
	Molecular Function	Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding	Protein Tyrosine Phosphatase Activity Prenylated Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomeric DNA Binding Positive Regulation Of Protein Localization To Nucleolus	Regulation Of Transcription, DNA-templated Peptidyl-tyrosine Dephosphorylation Endothelial Cell Migration Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Establishment Of Protein Localization
Pathways
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder ( 30804558) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte counts ( 32888494 27863252) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Monocyte count ( 32888494) Retinal vascular caliber ( 21060863) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899 32154731) Triglycerides ( 24097068 30275531 20686565) Type 2 diabetes ( 30054458) White blood cell count ( 32888494 27863252)	Diastolic blood pressure ( 27841878) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Response to antidepressants (symptom improvement) ( 29160301) Systolic blood pressure ( 27841878)
Interacting Genes		16 interacting genes: AIDA APP C14orf119 CACYBP EIF1AD GABPA GYS1 MCRS1 MPZ PAFAH1B2 TERF1 TERT TLK1 TNPO2 TP63 UBL5	4 interacting genes: CDKN2A FNTA FNTB FZR1
Entrez ID		54984	11156
HPRD ID		05934	05922
Ensembl ID		ENSG00000254093	ENSG00000184489
Uniprot IDs		Q96BK5	O75365
PDB IDs			1R6H 1V3A 2MBC 5TSR
Enriched GO Terms of Interacting Partners?
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