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NUTM2F and FADD
Data Source:
BioGRID
(two hybrid)
NUTM2F
FADD
Description
NUT family member 2F
Fas associated via death domain
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Neuron Projection
Cell Body
Membrane Raft
Ripoptosome
Molecular Function
Protease Binding
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Tumor Necrosis Factor Receptor Superfamily Binding
Receptor Serine/threonine Kinase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Caspase Binding
Biological Process
Kidney Development
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Adaptive Immune Response
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Surface Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Viral Process
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
T Cell Differentiation In Thymus
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Morphine
Innate Immune Response
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Behavioral Response To Cocaine
Lymph Node Development
Spleen Development
Thymus Development
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Necroptotic Process
Negative Regulation Of Activation-induced Cell Death Of T Cells
Cellular Response To Mechanical Stimulus
Death-inducing Signaling Complex Assembly
Motor Neuron Apoptotic Process
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of Cysteine-type Endopeptidase Activity
Necroptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Caspase activation via Death Receptors in the presence of ligand
TRIF-mediated programmed cell death
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Dimerization of procaspase-8
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS
Body mass index (
28892062
)
Peripheral arterial disease (traffic-related air pollution interaction) (
27082954
)
Diverticular disease (
30177863
)
Interacting Genes
20 interacting genes:
ANKS1A
ATXN1L
C1orf109
FADD
GRB2
HGS
LENG8
MORN4
NCK1
NCK2
NFYC
OSTF1
PRPF18
RAD23A
RBM47
SH3GL1
SH3RF1
VPS37C
ZMYND10
ZNF148
54 interacting genes:
ABCA1
ANK3
ATG5
BTG1
CASP10
CASP8
CASP8AP2
CFLAR
CSNK1A1
DAP3
DAPK1
DDIT4L
DDX24
DEDD
EDA2R
FAF1
FAS
FASLG
HIPK3
IKBKG
IRAK1
LRRCC1
MBD4
MKRN1
MOB4
MYD88
NACA
NOL3
NUTM2F
PARK7
PEA15
PIDD1
PIN1
PRKCZ
PTPN13
RALBP1
RAP1A
RIPK1
RNF4
RYBP
SDCBP
STAT1
STUB1
TAB1
TCEA2
TNFRSF10A
TNFRSF10B
TRADD
TRAF2
TRIM21
UBE2I
XPO5
ZCCHC12
ZMYM5
Entrez ID
54754
8772
HPRD ID
19318
03909
Ensembl ID
ENSG00000130950
ENSG00000168040
Uniprot IDs
A1L443
Q13158
PDB IDs
1A1W
1A1Z
1E3Y
1E41
2GF5
3EZQ
3OQ9
6ACI
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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