PDP1 and ACAT1

Data Source:
BioGRID (pull down)

		PDP1	ACAT1
Description		pyruvate dehydrogenase phosphatase catalytic subunit 1	acetyl-CoA acetyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix Extracellular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (lipoamide)] Phosphatase Activity Protein Binding Metal Ion Binding	Acetyl-CoA C-acetyltransferase Activity C-acetyltransferase Activity Potassium Ion Binding
	Biological Process	Protein Dephosphorylation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Peptidyl-threonine Dephosphorylation Positive Regulation Of Pyruvate Dehydrogenase Activity	Acetyl-CoA Biosynthetic Process Isoleucine Catabolic Process Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Cholesterol Esterification Acetyl-CoA Catabolic Process Ketone Body Biosynthetic Process Ketone Body Catabolic Process Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex	Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies
Drugs			Sulfasalazine Cannabidiol Medical Cannabis Nabiximols
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS			Nonunion in individuals with fractures ( 30680360) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 INCA1 KRTAP6-2 MEOX2 PDHA1 PRKCD SIRT3	4 interacting genes: AGXT PDP1 PEX7 PTPRF
Entrez ID		54704	38
HPRD ID		16185	01946
Ensembl ID		ENSG00000164951	ENSG00000075239
Uniprot IDs		A0A024R9C0 Q6P1N1 Q9P0J1	A0A140VJX1 A0A5F9ZHJ0 P24752
PDB IDs			2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY
Enriched GO Terms of Interacting Partners?
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