P4HTM and GPR37

Data Source:
BioGRID (two hybrid)

		P4HTM	GPR37
Description		prolyl 4-hydroxylase, transmembrane	G protein-coupled receptor 37
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Calcium Ion Binding 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Erythrocyte Differentiation	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Ascorbic acid
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 32341527 26237428) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: F2RL1 GLP1R GPR37 LTB4R2 PDIA2 RHOU UBC	51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11
Entrez ID		54681	2861
HPRD ID		17842	03992
Ensembl ID		ENSG00000178467	ENSG00000170775
Uniprot IDs		Q9NXG6	O15354
PDB IDs
Enriched GO Terms of Interacting Partners?
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