PARP14 and NPHP3

Data Source:
BioGRID (affinity chromatography technology)

		PARP14	NPHP3
Description		poly(ADP-ribose) polymerase family member 14	nephrocystin 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane	Extracellular Region Cytosol Cilium
	Molecular Function	Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Protein Binding Enzyme Binding Protein ADP-ribosylase Activity	Protein Binding
	Biological Process	Protein ADP-ribosylation Negative Regulation Of Gene Expression Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Innate Immune Response Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Protein Poly-ADP-ribosylation Protein Mono-ADP-ribosylation Positive Regulation Of Interleukin-4-mediated Signaling Pathway	Kidney Development Heart Looping Atrial Septum Development Determination Of Left/right Symmetry Wnt Signaling Pathway Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways		Nicotinamide salvaging Maturation of nucleoprotein Maturation of nucleoprotein	Trafficking of myristoylated proteins to the cilium
Drugs
Diseases			Senior-Loken syndrome Renal-hepatic-pancreatic dysplasia Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS			Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 27182965 21102462) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: GPI PARP10	3 interacting genes: ATXN1 DYSF NPHP1
Entrez ID		54625	27031
HPRD ID		11421	06417
Ensembl ID		ENSG00000173193	ENSG00000113971
Uniprot IDs		Q460N5 Q8N546	Q7Z494
PDB IDs		3GOY 3Q6Z 3Q71 3SE2 3SMI 3SMJ 3VFQ 4ABK 4ABL 4D86 4F1L 4F1Q 4PY4 5LXP 5LYH 5NQE 5O2D 5QHT 5QHU 5QHV 5QHW 5QHX 5QHY 5QHZ 5QI0 5QI1 5QI2 5QI3 5QI4 5QI5 5QI6 5QI7 5QI8 5QI9 5QIA 5V7T 5V7W 6FYM 6FZM 6G0W 7D2C	5L7K
Enriched GO Terms of Interacting Partners?
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