EGLN1 and VHL

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EGLN1	VHL
Description		egl-9 family hypoxia inducible factor 1	von Hippel-Lindau tumor suppressor
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane
	Molecular Function	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Oxygen Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Response To Nitric Oxide	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Transcription, DNA-templated Proteolysis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Stabilization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Ascorbic acid Iron Roxadustat N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE FG-2216 Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)	Renal cell carcinoma von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High altitude adaptation ( 28373541) Metabolite levels ( 23823483) Red blood cell count ( 32888494 27863252)
Interacting Genes		11 interacting genes: EPAS1 HIF1A HIF3A HSP90AA1 ING4 KRAS OS9 PLD1 SRC VHL ZNF281	107 interacting genes: ACTB AKT1 APP AR AURKA CAPN7 CAPZB CASR CBR1 CBX1 CBX3 CCNC CCT3 CD44 CDC34 CDKN2A CERKL CHEK2 CLU COL4A2 CSNK2A1 CUL2 CUL5 DGKI DNAJA3 DVL2 E2F1 EEF1B2 EGLN1 ELOB ELOC EPAS1 EPOR FKBP8 FLNA FN1 GHET1 GPS1 H1-2 H2BC13 H4-16 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HNRNPA2B1 HNRNPD HSF2BP HSPA5 HSPA8 IKBKB JADE1 KIF2C KIF3A KLF4 LANCL1 MAP1LC3B MDFI NCL NR4A1 NR4A2 NR4A3 PDCD5 PIAS4 PLD1 PLD2 POLR2G PPP5C PRDX1 PRKCI PRMT1 PRMT8 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RHOBTB3 RNF139 RPL21 RPL5 RPS15A RWDD3 SARNP SAT2 SKP2 SLC2A1 SLC3A2 SON SP1 TPT1 TRIM28 UBE2D1 UBE2D2 UBE2I UBE2S USP20 USP33 USP9X UXT VAPB VBP1 YY1AP1 ZNF197 ZNF512B
Entrez ID		54583	7428
HPRD ID		06971	01905
Ensembl ID		ENSG00000135766	ENSG00000134086
Uniprot IDs		Q9GZT9 R4SCQ0	A0A024R2F2 A0A0S2Z4K1 P40337
PDB IDs		2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ 6QGV 6ST3 6YVT	1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I7Q 6I7R 6R6H 6R7F 6SIS 6ZHC
Enriched GO Terms of Interacting Partners?
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