POU3F1 and ST3GAL3

Data Source:
BioGRID (affinity chromatography technology)

		POU3F1	ST3GAL3
Description		POU class 3 homeobox 1	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Axon Ensheathment Positive Regulation Of Gene Expression Myelination In Peripheral Nervous System Keratinocyte Differentiation Forebrain Development Positive Regulation Of Transcription, DNA-templated	Protein Glycosylation O-glycan Processing Keratan Sulfate Biosynthetic Process Sialylation
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis
Drugs
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Rheumatoid arthritis ( 23143596 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-to-hip circumference ratio (ever vs never smoking interaction) ( 23192594)	Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256)
Interacting Genes		3 interacting genes: HMGA1 HMGB2 POU3F4	5 interacting genes: ACTG1 RPL8 SCAMP2 TTR ZBTB5
Entrez ID		5453	6487
HPRD ID		03921	05930
Ensembl ID		ENSG00000185668	ENSG00000126091
Uniprot IDs		Q03052	A0A2R8Y732 Q11203
PDB IDs
Enriched GO Terms of Interacting Partners?
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