POU1F1 and ARSA

Data Source:
BioGRID (two hybrid)

		POU1F1	ARSA
Description		POU class 1 homeobox 1	arylsulfatase A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Extracellular Region Lysosome Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Adenohypophysis Development Positive Regulation Of Transcription By RNA Polymerase II	Glycosphingolipid Metabolic Process Neutrophil Degranulation
Pathways			Glycosphingolipid metabolism The activation of arylsulfatases Neutrophil degranulation
Drugs			4-Nitrocatechol sulfate 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Metachromatic leukodystrophy (MLD)
GWAS		Menarche (age at onset) ( 25231870) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Blood metabolite levels ( 24816252) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) QT interval (ambient particulate matter interaction) ( 28749367) Urinary metabolite levels in chronic kidney disease ( 31959995) vWF and FVIII levels ( 30586737)
Interacting Genes		22 interacting genes: ARID5A ARSA CREBBP ETS1 GATA2 JUN KRTAP10-8 KRTAP15-1 KRTAP6-1 LASP1 LHX4 MSX2 NCOR1 NR1I2 NR1I3 NR3C1 PITX1 PPARA PPARG RAD54L2 UBE2I VDR	18 interacting genes: ANXA11 BMPR2 CAMK2B CCDC22 CETN2 CLEC4G CTSL EID2B FOXI1 GAL3ST1 PKN1 POU1F1 PPIC PROP1 RHOXF2 SNCA TRIP13 VENTX
Entrez ID		5449	410
HPRD ID		01409	09617
Ensembl ID		ENSG00000064835	ENSG00000100299
Uniprot IDs		P28069	A0A0C4DFZ2 B4DVI5 P15289
PDB IDs		5WC9	1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8
Enriched GO Terms of Interacting Partners?
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