CHPF2 and PRKAG2

Data Source:
BioGRID (proximity labelling technology)

		CHPF2	PRKAG2
Description		chondroitin polymerizing factor 2	protein kinase AMP-activated non-catalytic subunit gamma 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Membrane Integral Component Of Membrane Golgi Cisterna Membrane	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Acetylgalactosaminyltransferase Activity Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity Phosphorylase Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Kinase Activator Activity ADP Binding
	Biological Process	Chondroitin Sulfate Biosynthetic Process	Glycogen Metabolic Process Regulation Of Glycolytic Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Fatty Acid Biosynthetic Process ATP Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Positive Regulation Of Peptidyl-threonine Phosphorylation Sterol Biosynthetic Process Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Metabolic Process Activation Of Protein Kinase Activity Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Protein Kinase Activity Regulation Of Fatty Acid Oxidation Regulation Of Glucose Import Regulation Of Catalytic Activity Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Chondroitin sulfate biosynthesis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS		Eyebrow thickness ( 26926045) Multiple myeloma ( 27363682)	Bipolar disorder (age of onset and psychotic symptoms) ( 21305692) Blood urea nitrogen levels ( 31152163) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in diabetes ( 29703844) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glomerular filtration rate in type 2 diabetes ( 29703844) Gut microbiota (beta diversity) ( 27723756) Hematocrit ( 32888494 27863252 28017375 19862010) Hemoglobin ( 32888494 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) Intraocular pressure ( 29785010 31959993) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolite levels (small molecules and protein measures) ( 27005778) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494 28453575 27863252) Red blood cell traits ( 23222517) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 27618447 30578418) Urate levels ( 31578528 23263486) Urea levels ( 31015462 28270201) Urinary albumin excretion ( 32277301)
Interacting Genes			5 interacting genes: DAPK1 MFHAS1 PRKAB1 PRKAB2 PRKAG1
Entrez ID		54480	51422
HPRD ID		10474	04119
Ensembl ID		ENSG00000033100	ENSG00000106617
Uniprot IDs		B3KPG6 G5E9W2 Q9P2E5	A0A090N8Q6 A0A384MDZ2 A0A494C068 A0A494C1K7 B7Z6X8 E9PGP6 Q9UGJ0
PDB IDs
Enriched GO Terms of Interacting Partners?
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