PRR13 and MSX2

Data Source:
BioGRID (two hybrid)

		PRR13	MSX2
Description		proline rich 13	msh homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Chromatin Nucleus Cytosol Nuclear Speck
	Molecular Function	Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Cranial Suture Morphogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Regulation of RUNX2 expression and activity
Drugs
Diseases			Enlarged parietal foramina/cranium bifidum Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Blond vs. brown/black hair color ( 30531825) Chin dimples ( 27182965) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Red vs. brown/black hair color ( 30531825) Resistant hypertension ( 30237584) Stroke ( 26089329)
Interacting Genes		52 interacting genes: AP2M1 BAIAP2 CBLL2 CELF5 DAZAP2 DVL3 EWSR1 FAM133A FUBP1 GPAA1 H2BC15 IL16 KHDC4 KLHL12 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP13-1 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP4-12 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LGALS3 LNX1 MSX2 NKX1-2 OTX1 PEX5 PLSCR1 PPIA PSMA3 PSME3 RBM47 RP9P RTN4 SDCBP SDCBP2 SMUG1 SREK1IP1 SRI TIAL1 TNFAIP8 TRIP13 VAC14 YPEL3 ZCCHC10	54 interacting genes: ATXN1 CCDC102B CEBPA CLIC3 DLX2 DLX5 EPHB6 FBXW2 FOXH1 GATA2 GTF2F1 GTF2F2 HOXC9 LENG8 MAGED1 MAPK1 MAPK1IP1L MGAT5B MSX1 NAF1 NR3C1 PATZ1 PIAS2 PITX1 POLR3D POU1F1 POU2AF1 POU2F2 POU6F2 PPARG PRR13 RBPMS2 RHOXF2 ROR2 RUNX2 SMAP2 SOX5 SPEN TCF7L2 TENT5D TLE1 TLE2 TLE5 TLX3 TOLLIP TSSK3 VEZF1 XRCC5 XRCC6 YTHDF1 ZBTB17 ZC3H10 ZDHHC2 ZFHX3
Entrez ID		54458	4488
HPRD ID		13211	00421
Ensembl ID		ENSG00000205352	ENSG00000120149
Uniprot IDs		A0A024RB45 Q9NZ81	P35548
PDB IDs
Enriched GO Terms of Interacting Partners?
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