WNT4 and PORCN

Data Source:
HPRD (in vitro, in vivo)

		WNT4	PORCN
Description		Wnt family member 4	porcupine O-acyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse
	Molecular Function	Transcription Corepressor Activity Frizzled Binding Cytokine Activity Receptor Ligand Activity	Transferase Activity, Transferring Acyl Groups Wnt-protein Binding Palmitoleoyltransferase Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Epithelial To Mesenchymal Transition Embryonic Epithelial Tube Formation Liver Development Male Gonad Development Female Gonad Development Cellular Response To Starvation Negative Regulation Of Gene Expression Negative Regulation Of Steroid Biosynthetic Process Wnt Signaling Pathway Regulation Of Cell-cell Adhesion Neuron Differentiation Female Sex Determination Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Immature T Cell Proliferation In Thymus Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Hormone Metabolic Process Positive Regulation Of GTPase Activity Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Oocyte Development Smooth Muscle Cell Differentiation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Mesenchymal To Epithelial Transition Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Wound Healing Mammary Gland Epithelium Development Positive Regulation Of Dermatome Development Paramesonephric Duct Development Negative Regulation Of Testicular Blood Vessel Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Formation Renal Vesicle Induction Metanephric Mesenchymal Cell Differentiation Metanephric Tubule Formation Metanephric Nephron Morphogenesis Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Protein Palmitoylation Lipid Modification Protein Palmitoleylation Canonical Wnt Signaling Pathway Wnt Protein Secretion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists PCP/CE pathway PCP/CE pathway	WNT ligand biogenesis and trafficking LGK974 inhibits PORCN
Drugs
Diseases		46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD	Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Birth weight ( 31043758 27680694) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Bone mineral density (total hip) ( 29883787) Colorectal cancer ( 25990418) Daytime sleep phenotypes ( 27126917) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Dupuytren's disease ( 28886342 21732829) Endometriosis ( 23104006 23472165 20601957 28333195 28537267) Epithelial ovarian cancer ( 25581431) Extremely high intelligence ( 29520040) Gestational age at birth (maternal effect) ( 28877031) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412) Lumbar spine bone mineral density ( 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Pelvic organ prolapse ( 32184442) Right-sided colonic diverticulosis ( 31089239) Spine bone size ( 31053729) Systolic blood pressure ( 30224653) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Thyroid stimulating hormone levels ( 32769997) Uterine fibroids ( 31488892 31249589 30194396 31649266) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		8 interacting genes: APP FZD6 LGALS3BP P2RX4 PORCN SFRP1 SFRP2 TMEM80	9 interacting genes: APOC2 APOC4 CBARP WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B
Entrez ID		54361	64840
HPRD ID		04601	06680
Ensembl ID		ENSG00000162552	ENSG00000102312
Uniprot IDs		P56705	Q9H237
PDB IDs
Enriched GO Terms of Interacting Partners?
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