POLH and POLI

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		POLH	POLI
Description		DNA polymerase eta	DNA polymerase iota
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Cytosol Site Of Double-strand Break	Nucleoplasm Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA Repair Regulation Of DNA Repair Pyrimidine Dimer Repair Response To Radiation Response To UV-C Translesion Synthesis Error-prone Translesion Synthesis Error-free Translesion Synthesis Cellular Response To UV-C	DNA Replication DNA Repair Translesion Synthesis Error-prone Translesion Synthesis
Pathways		Translesion Synthesis by POLH Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR)	Translesion synthesis by POLI Termination of translesion DNA synthesis
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31361310 30929738 32296059) Asthma (childhood onset) ( 30929738) Eosinophil percentage of white cells ( 32888494) Inflammatory skin disease ( 25574825)
Interacting Genes		9 interacting genes: APP DYNLL1 PCNA POLD2 POLI REV1 RPS27A UBC WBP2	21 interacting genes: APP CALCOCO2 DAZAP2 DVL2 EP300 HOMER3 MFHAS1 MTNR1B NEDD8 PCNA POLH REV1 RNF11 TMEM239 TRAF6 TRIM23 TRIM39 UBA52 UBB UBC ZBTB44
Entrez ID		5429	11201
HPRD ID		04913	16094
Ensembl ID		ENSG00000170734	ENSG00000101751
Uniprot IDs		A0A024RD62 B3KN75 B4DG64 Q9Y253	Q9UNA4
PDB IDs		2I5O 2LSK 3JAA 3MR2 3MR3 3MR5 3MR6 3SI8 3TQ1 3WUP 4DL2 4DL3 4DL4 4DL5 4DL6 4DL7 4ECQ 4ECR 4ECS 4ECT 4ECU 4ECV 4ECW 4ECX 4ECY 4ECZ 4ED0 4ED1 4ED2 4ED3 4ED6 4ED7 4ED8 4EEY 4J9K 4J9L 4J9M 4J9N 4J9O 4J9P 4J9Q 4J9R 4J9S 4O3N 4O3O 4O3P 4O3Q 4O3R 4O3S 4Q8E 4Q8F 4RNM 4RNN 4RNO 4RU9 4YP3 4YQW 4YR0 4YR2 4YR3 5DG7 5DG8 5DG9 5DGA 5DGB 5DLF 5DLG 5DQG 5DQH 5DQI 5EWE 5EWF 5EWG 5F9L 5F9N 5JUM 5KFA 5KFB 5KFC 5KFD 5KFE 5KFF 5KFG 5KFH 5KFI 5KFJ 5KFK 5KFL 5KFM 5KFN 5KFO 5KFP 5KFQ 5KFR 5KFS 5KFT 5KFU 5KFV 5KFW 5KFX 5KFY 5KFZ 5KG0 5KG1 5KG2 5KG3 5KG4 5KG5 5KG6 5KG7 5L1I 5L1J 5L1K 5L1L 5L9X 6D0M 6D0Z 6M7O 6M7P 6M7T 6M7U 6M7V 6MP3 6MQ8 6MXO 6PL7 6PL8 6PLC 6PZ3 6Q02 6UI2 6UQI	1T3N 1ZET 2ALZ 2DPI 2DPJ 2FLL 2FLN 2FLP 2KHU 2KHW 2KTF 2L0F 2L0G 2MBB 3EPG 3EPI 3G6V 3G6X 3G6Y 3GV5 3GV7 3GV8 3H40 3H4B 3H4D 3NGD 3OSN 3Q8P 3Q8Q 3Q8R 3Q8S 4EBC 4EBD 4EBE 4EYH 4EYI 4FS1 4FS2 5KT2 5KT3 5KT4 5KT5 5KT6 5KT7 5ULW 5ULX
Enriched GO Terms of Interacting Partners?
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