PELO and HBS1L

Data Source:
BioGRID (two hybrid, two hybrid)

		PELO	HBS1L
Description		pelota mRNA surveillance and ribosome rescue factor	HBS1 like translational GTPase
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol Membrane Extracellular Exosome
	Molecular Function	Endonuclease Activity Protein Binding Metal Ion Binding	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding
	Biological Process	Inner Cell Mass Cell Proliferation Cell Cycle Endoderm Development Stem Cell Population Maintenance Positive Regulation Of BMP Signaling Pathway Ribosome Disassembly Chromosome Organization Cell Division Mesenchymal To Epithelial Transition Nuclear-transcribed MRNA Catabolic Process, Non-stop Decay Nonfunctional RRNA Decay Nuclear-transcribed MRNA Catabolic Process, No-go Decay RNA Surveillance Nucleic Acid Phosphodiester Bond Hydrolysis	Translation Translational Elongation Signal Transduction Exonucleolytic Catabolism Of Deadenylated MRNA
Pathways			mRNA decay by 3' to 5' exoribonuclease
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Low density lipoprotein cholesterol levels ( 32154731) Presence of antiphospholipid antibodies ( 23509613) Response to platinum-based agents ( 22020760) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum total protein level ( 29403010) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010) Beta thalassemia/hemoglobin E disease ( 20183929) Cholesterol, total ( 24097068) Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736) Granulocyte count ( 27863252) HbA2 levels ( 23043469) Hematocrit ( 29403010 32888494 27863252 28017375 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hodgkin's lymphoma ( 24149102) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549 28334899) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 23263863 29403010 32888494 19853236 28453575 20139978 27863252 28017375 28548082 19862010 28031487) Mean corpuscular hemoglobin concentration ( 23263863 29403010 32888494 20139978 27863252 28017375) Mean corpuscular volume ( 23263863 29403010 32888494 19853236 28453575 20139978 27863252 28017375 19862010 28031487) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Other erythrocyte phenotypes ( 19862010) Platelet count ( 26805783 22139419 24026423 29066854 29403010 32888494 19853236 22423221 20139978 27863252 28031487) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010 32888494 28453575 20139978 27863252 28017375 28031487) Red blood cell traits ( 20927387 23935956 23222517) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 30275531) White blood cell count ( 29403010 32888494 20139978 27863252) White blood cell types ( 21738478)
Interacting Genes		13 interacting genes: DYNLT1 FLNA HBS1L HSPB1 KRTAP12-2 LMO3 LMO4 MEOX2 PIK3R3 PRMT6 PTEN TRIM55 TRIM63	10 interacting genes: APP EXOSC4 EXOSC5 EXOSC6 EXOSC9 MAP3K1 PELO SRPK1 SRPK2 UBE2G2
Entrez ID		53918	10767
HPRD ID		09309	06582
Ensembl ID		ENSG00000152684	ENSG00000112339
Uniprot IDs		Q9BRX2	D9YZV0 Q9Y450
PDB IDs		1X52 5EO3 5LZW 5LZX 5LZY 5LZZ	5LZW 5LZX 5LZY 5LZZ
Enriched GO Terms of Interacting Partners?
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