RIPPLY3 and ORC2

Data Source:
BioGRID (two hybrid)

		RIPPLY3	ORC2
Description		ripply transcriptional repressor 3	origin recognition complex subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane
	Molecular Function	Protein Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Development Biological_process Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Pharyngeal System Development	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation
Pathways			E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS			Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		7 interacting genes: CEP76 INCA1 MCRS1 ORC2 PSMB1 TIFA TRAF2	28 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RIPPLY3 RPA1 RPA2 XRCC5
Entrez ID		53820	4999
HPRD ID		10923	03112
Ensembl ID		ENSG00000183145	ENSG00000115942
Uniprot IDs		P57055	A0A024R411 Q13416
PDB IDs			5C8H 5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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