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PML and THRA
Data Source:
HPRD
(in vivo)
PML
THRA
Description
PML nuclear body scaffold
thyroid hormone receptor alpha
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
Early Endosome Membrane
Extrinsic Component Of Endoplasmic Reticulum Membrane
Chromatin
Nucleus
Nucleoplasm
Cytosol
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
SUMO Binding
Protein Homodimerization Activity
SMAD Binding
Sumo-dependent Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
TBP-class Protein Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Protein-containing Complex Binding
Thyroid Hormone Binding
Biological Process
Response To Hypoxia
Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Protein Import Into Nucleus
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Response To UV
Response To Gamma Radiation
Regulation Of Calcium Ion Transport Into Cytosol
Fibroblast Migration
Viral Process
Negative Regulation Of Angiogenesis
Protein Ubiquitination
Myeloid Cell Differentiation
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
PML Body Organization
Positive Regulation Of Telomere Maintenance
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Interleukin-1 Beta Production
Circadian Regulation Of Gene Expression
Response To Cytokine
Regulation Of Circadian Rhythm
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Entrainment Of Circadian Clock By Photoperiod
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Cell Fate Commitment
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fibroblast Proliferation
Retinoic Acid Receptor Signaling Pathway
Maintenance Of Protein Location In Nucleus
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Branching Involved In Mammary Gland Duct Morphogenesis
Protein-containing Complex Assembly
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Interleukin-4
Cellular Senescence
Extrinsic Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Double-strand Break Repair
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Cartilage Condensation
Ossification
Thyroid Hormone Mediated Signaling Pathway
Regulation Of Thyroid Hormone Mediated Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Learning Or Memory
Regulation Of Heart Contraction
Female Courtship Behavior
Response To Cold
Hormone-mediated Signaling Pathway
Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Cell Differentiation
Erythrocyte Differentiation
Thyroid Gland Development
Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Female Receptivity
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Lipid Catabolic Process
Type I Pneumocyte Differentiation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of DNA-templated Transcription, Initiation
Pathways
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Regulation of TP53 Activity through Acetylation
Interferon gamma signaling
Regulation of RUNX1 Expression and Activity
Regulation of PTEN localization
HCMV Early Events
Nuclear Receptor transcription pathway
Drugs
Arsenic trioxide
Liothyronine
Levothyroxine
Dextrothyroxine
Amiodarone
Liotrix
KB-141
Dronedarone
Eprotirome
NRP409
Thyroid, porcine
Diseases
Acute myeloid leukemia (AML)
GWAS
Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) (
29899525
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Height (
28552196
20881960
25282103
)
Insomnia symptoms (never/rarely vs. sometimes/usually) (
30804566
)
Insomnia symptoms (never/rarely vs. usually) (
30804566
)
Myopia (pathological) (
23049088
)
Paget's disease (
21623375
)
Physical activity (overall physical activity time) (
30531941
)
White blood cell count (
32888494
)
Asthma (
31619474
)
Bipolar disorder (
31043756
)
Chronic obstructive pulmonary disease (
30804561
)
Pancreatic ductal adenocarcinoma (
30541042
)
White blood cell count (
21738480
)
Interacting Genes
109 interacting genes:
ADH1B
ANKRD2
ARID3A
ARNT
ATF2
ATXN1
AURKA
AXIN1
BANP
BCL2
BCL6
CASP8AP2
CCNT1
CDK1
CDK2
CDK6
CHFR
CREBBP
CSNK2A1
DAXX
EGFR
EIF4E
ELF4
EP300
ERCC6
FOS
GATA1
GATA2
HDAC1
HDAC2
HDAC3
HHEX
HIPK2
HTT
KAT5
KAT6A
KLHL20
MAD1L1
MAPK11
MAPK14
MDM2
MED7
MXD1
MYB
MYC
NACC1
NCOA2
NCOR1
NCOR2
NFKB1
NR3C1
NR4A1
PAWR
PAXIP1
PCBD2
PIAS1
PIAS2
PIN1
PLAGL1
PLSCR1
POLR2E
PPARG
PSMA3
RARA
RB1
RBX1
RELA
RNF111
RNF125
RPL11
RXRA
SENP1
SENP2
SH3GL1
SIAH2
SIN3A
SIRT1
SKI
SMAD3
SP1
SP100
SRF
STAT3
SUMO1
SUMO2
SUMO3
SUV39H1
SYNE2
TDG
TERF2IP
TGFBR1
TGFBR2
TGIF1
THRA
TOPBP1
TP53
TP63
TP73
TRIB3
TRIM24
TRIM27
TRIM69
UBE2I
UBE2U
UBE3A
USP11
ZBTB16
ZFYVE9
ZNF451
69 interacting genes:
-
AKAP13
AMOT
AMOTL2
ARID5A
BTG1
BUB3
C1D
CCND1
CD160
CDK7
CEP76
CLIC1
COPS2
CREB1
CREBBP
CUL1
DAP3
ESR1
FOXJ1
FUS
GRIP1
GTF2B
HDAC2
HDAC3
ITGB3BP
L3MBTL3
MED1
MED21
MED25
MEF2A
MEOX2
MTNR1B
NCOA1
NCOA2
NCOA6
NCOR1
NCOR2
NR0B2
NR2F1
NRIP1
NSD1
OASL
PML
POU2F1
PRKAR1B
PRKDC
PTGES3
RANBP9
RGN
RXRA
RXRB
RXRG
SELENOP
SLC16A2
SRC
SUV39H1
SYAP1
TACC1
TBL1X
TDG
TRIM24
TRIM63
TRIP11
TXNRD1
UBE2I
YWHAH
YWHAQ
ZBTB3
Entrez ID
5371
7067
HPRD ID
00023
07185
Ensembl ID
ENSG00000140464
ENSG00000126351
Uniprot IDs
P29590
P10827
Q6FH41
PDB IDs
1BOR
2MVW
2MWX
4WJN
4WJO
5YUF
6IMQ
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
1NAV
2H77
2H79
3HZF
3ILZ
3JZB
4LNW
4LNX
Enriched GO Terms of Interacting Partners
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