ATP6AP1 and NT5E

Data Source:
BioGRID (affinity chromatography technology)

		ATP6AP1	NT5E
Description		ATPase H+ transporting accessory protein 1	5'-nucleotidase ecto
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Endosome Membrane Integral Component Of Membrane Proton-transporting Two-sector ATPase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Proton-transporting V-type ATPase, V1 Domain Plasma Membrane Proton-transporting V-type ATPase Complex Extracellular Exosome	Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Small GTPase Binding	Nucleotide Binding Protein Binding 5'-nucleotidase Activity Metal Ion Binding
	Biological Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway Regulation Of Cellular PH Transferrin Transport Ion Transmembrane Transport Cellular Response To Increased Oxygen Levels Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Resorption PH Reduction Positive Regulation Of Exocytosis Establishment Of Organelle Localization Positive Regulation Of ERK1 And ERK2 Cascade Proton Transmembrane Transport Positive Regulation Of Osteoclast Development	Purine Nucleotide Catabolic Process AMP Catabolic Process DNA Metabolic Process Leukocyte Cell-cell Adhesion Dephosphorylation NAD Metabolic Process Adenosine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Negative Regulation Of Inflammatory Response
Pathways		Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport	Nicotinate metabolism Pyrimidine catabolism Purine catabolism Purinergic signaling in leishmaniasis infection
Drugs		Tiludronic acid	Pentoxifylline
Diseases			Calcification of joints and arteries
GWAS			Blood metabolite levels ( 24816252) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lung function ( 31902109) Metabolic traits ( 21886157)
Interacting Genes		5 interacting genes: ANG ERBB2 HBA1 NR1I2 RHOU	6 interacting genes: ACTB AFF1 FN1 LAMA1 RNF24 ZNRF4
Entrez ID		537	4907
HPRD ID		02184	00552
Ensembl ID		ENSG00000071553	ENSG00000135318
Uniprot IDs		A0A0C4DGX8 A0A384MQW4 Q15904	P21589 Q6NZX3
PDB IDs			4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I 6HXW 6S7F 6S7H 6TVE 6TVG 6TVX 6TW0 6TWA 6TWF 6XUE 6XUG 6XUQ 6Z9B 6Z9D 7JV8 7JV9
Enriched GO Terms of Interacting Partners?
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