PLXNA2 and DHX37

Data Source:
HPRD (two hybrid)

		PLXNA2	DHX37
Description		plexin A2	DEAH-box helicase 37
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane	Intracellular Anatomical Structure Nucleoplasm Nucleolus Cytoplasm Nuclear Membrane
	Molecular Function	Protein Binding Semaphorin Receptor Activity Identical Protein Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding U3 SnoRNA Binding
	Biological Process	Somitogenesis Negative Regulation Of Cell Adhesion Regulation Of Cell Shape Neural Tube Development Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Centrosome Localization Pharyngeal System Development Limb Bud Formation Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Brain Development Ribosome Biogenesis Ribosome Assembly Positive Regulation Of Male Gonad Development
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091) Bitter alcoholic beverage consumption ( 31046077) Cardiac hypertrophy ( 21348951) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) General risk tolerance (MTAG) ( 30643258) Lung cancer in never smokers ( 28604730) Manganese levels ( 26025379) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730)	HDL cholesterol levels ( 32203549) Hip circumference ( 28552196) Insulin levels in response to oral glucose tolerance test (120 minutes) ( 29093273)
Interacting Genes		6 interacting genes: CEMIP DHX37 FNBP4 HACE1 IFT80 UBAP2L	55 interacting genes: ATXN1 KIFAP3 KRT31 MIR1-1 MIR1-2 MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR143 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR199A1 MIR19B1 MIR19B2 MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR25 MIR29A MIR34A MIR34B MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PLXNA2 RGS17 TRIP6
Entrez ID		5362	57647
HPRD ID		03033	10883
Ensembl ID		ENSG00000076356	ENSG00000150990
Uniprot IDs		O75051	Q8IY37
PDB IDs		3Q3J
Enriched GO Terms of Interacting Partners?
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