PLEC and ITGA6

Data Source:
HPRD (in vitro, two hybrid)

		PLEC	ITGA6
Description		plectin	integrin subunit alpha 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Membrane Sarcoplasm Hemidesmosome Sarcolemma Costamere Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Filopodium Integrin Alpha6-beta4 Complex
	Molecular Function	RNA Binding Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Ankyrin Binding Cadherin Binding	Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding
	Biological Process	Hemidesmosome Assembly Wound Healing Intermediate Filament Cytoskeleton Organization	Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Extracellular Matrix Organization Positive Regulation Of Cell Migration Hemidesmosome Assembly Cell-substrate Adhesion Nail Development Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Skin Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Migration Cellular Response To Organic Cyclic Compound Cell-cell Adhesion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly	Assembly of collagen fibrils and other multimeric structures Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions Type I hemidesmosome assembly
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Anti-saccade response ( 29064472) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fibrinogen levels ( 28107422 26561523) Height ( 31562340) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)	Alzheimer's disease biomarkers ( 23419831) Blood protein levels ( 28240269) Diabetic kidney disease ( 26305897) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Food allergy ( 29030101) Metabolite levels ( 23823483) Peanut allergy ( 29030101) Prostate cancer ( 31562322 19767753)
Interacting Genes		24 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 EGFR ITGA6 ITGB4 LMNB1 MAP2 MSN MTDH PLEKHA5 PTEN RACK1 SMAD9 SNAPIN SPTA1 SPTAN1 SUMO2 UBC VIM	22 interacting genes: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 LGALS3BP PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4
Entrez ID		5339	3655
HPRD ID		03180	00945
Ensembl ID		ENSG00000178209	ENSG00000091409
Uniprot IDs		Q15149	P23229
PDB IDs		1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I
Enriched GO Terms of Interacting Partners?
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