TPCN1 and IFT81

Data Source:
BioGRID (proximity labelling technology)

		TPCN1	IFT81
Description		two pore segment channel 1	intraflagellar transport 81
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endosome Membrane Integral Component Of Membrane	Centrosome Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Ciliary Tip
	Molecular Function	Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Identical Protein Binding Protein Homodimerization Activity NAADP-sensitive Calcium-release Channel Activity Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Tubulin Binding
	Biological Process	Positive Regulation Of Autophagy Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol	Spermatogenesis Regulation Of Smoothened Signaling Pathway Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Cilium Assembly
Pathways		Stimuli-sensing channels	Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Response to fenofibrate (adiponectin levels) ( 23149075)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Intelligence (MTAG) ( 29326435) Total intracranial volume ( 31530798)
Interacting Genes			2 interacting genes: APP IFT74
Entrez ID		53373	28981
HPRD ID		18217	09266
Ensembl ID		ENSG00000186815	ENSG00000122970
Uniprot IDs		B3KSG7 B7Z3R2 Q9ULQ1	A0A024RBJ1 Q8WYA0
PDB IDs
Enriched GO Terms of Interacting Partners?
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